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Mechanism of coupling periodate-oxidized nucleosides to proteins

Senapathy, P and Ali, MA and Jacob, MT (1985) Mechanism of coupling periodate-oxidized nucleosides to proteins. In: FEBS Letters, 190 (2). pp. 337-341.

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This paper describes a mechanism of coupling periodate-oxidized nucleosides to proteins. Each of the dialdehyde groups of a periodate-oxidized nucleoside is shown to couple to lysine residues on different protein molecules through Schiff bases, thereby cross-linking different protein molecules, forming a polymer. This is in contrast to the previous model in which nucleosides were suggested to couple to proteins through a morpholine structure. The cross-linked structure of the nucleoside-antigen, significantly different when compared to the native protein, may affect the specificity and the efficiency of antibody production.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science
Additional Information: The copyright of this article belongs to Elsevier Science
Keywords: Nucleoside-antigenPeriodate oxidationSchiff baseProtein cross-linkingPolymerizationAntibody production
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 13 Nov 2009 12:31
Last Modified: 19 Sep 2010 05:32
URI: http://eprints.iisc.ac.in/id/eprint/20234

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