Deshpande, SN and Vijayakumar, G and Rao, AJ (2009) Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis. In: Reproductive Biomedicine Online, 18 (4). pp. 555-561.
Full text not available from this repository. (Request a copy)Abstract
A role for oestrogen in regulating fluid reabsorption in the monkey epididymis was recently demonstrated. Here, these Studies are extended to identify potential oestrogen-regulated proteins in the cauda region of monkey epididymis treated with vehicle and oestrogen receptor antagonist (ICI 182780). Two-dimensional electrophoretic analysis was used to identify the proteins. The results indicated down-regulation of WNT4 in the ICI-182780-treated monkey cauda. In addition. the Wnt4f mRNA concentration was also reduced in the caput regions of ICI-182780-treated rats and oestrogen receptor knockout mice. WNT4 is a key regulator of gonadal differentiation in humans and mice and plays a pivotal role in early mouse embryogenesis. The results of the present Study establish the presence of WNT4 in the monkey epididymis and its regulation by oestrogen, and Suggest a role for WNT4 in maintaining epididymal homeostasis.
| Item Type: | Journal Article |
|---|---|
| Publication: | Reproductive Biomedicine Online |
| Publisher: | Reproductive Healthcare Ltd. |
| Additional Information: | Copyright of this article belongs to Reproductive Healthcare Ltd. |
| Keywords: | epididymis;monkey;oestrogen;WNT4 |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 01 Jan 2010 10:57 |
| Last Modified: | 01 Jan 2010 10:57 |
| URI: | http://eprints.iisc.ac.in/id/eprint/19919 |
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