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Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis

Deshpande, SN and Vijayakumar, G and Rao, AJ (2009) Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis. In: Reproductive Biomedicine Online, 18 (4). pp. 555-561.

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A role for oestrogen in regulating fluid reabsorption in the monkey epididymis was recently demonstrated. Here, these Studies are extended to identify potential oestrogen-regulated proteins in the cauda region of monkey epididymis treated with vehicle and oestrogen receptor antagonist (ICI 182780). Two-dimensional electrophoretic analysis was used to identify the proteins. The results indicated down-regulation of WNT4 in the ICI-182780-treated monkey cauda. In addition. the Wnt4f mRNA concentration was also reduced in the caput regions of ICI-182780-treated rats and oestrogen receptor knockout mice. WNT4 is a key regulator of gonadal differentiation in humans and mice and plays a pivotal role in early mouse embryogenesis. The results of the present Study establish the presence of WNT4 in the monkey epididymis and its regulation by oestrogen, and Suggest a role for WNT4 in maintaining epididymal homeostasis.

Item Type: Journal Article
Publication: Reproductive Biomedicine Online
Publisher: Reproductive Healthcare Ltd.
Additional Information: Copyright of this article belongs to Reproductive Healthcare Ltd.
Keywords: epididymis;monkey;oestrogen;WNT4
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 01 Jan 2010 10:57
Last Modified: 01 Jan 2010 10:57
URI: http://eprints.iisc.ac.in/id/eprint/19919

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