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Interaction of Co, Mn, Mg and AI with d(GCGTACGC): a spectroscopic study

Rajan, MT and Champion, D and Kumar, CS and Vishnuvardhan, D and Jagannatha Rao, KS and Viswamitra, MA (1996) Interaction of Co, Mn, Mg and AI with d(GCGTACGC): a spectroscopic study. In: Molecular Biology Reports, 22 (01). pp. 47-52.

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Spectroscopic study on the interactions of trace elements Co, Mn, Mg and Al with d(GCGTACGC) indicated the following: Al and Mg did not alter T-m values. Mn enhanced T-m at lower concentration and decreased it at higher concentrations. Interestingly Co at higher concentration elevated the T-m. These studies also showed lower concentrations of Mn displaced EtBr, whereas Al could displace it at higher ionic strength. Mg and Co displaced EtBr fluorescence at moderate concentrations. The binding constant values and CD spectra clearly indicated strong binding of these elements to DNA.

Item Type: Journal Article
Publication: Molecular Biology Reports
Publisher: Springer
Additional Information: Copyright of this article belongs to Springer.
Keywords: DNA;interaction;spectroscopy and trace elements.
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 25 Aug 2009 12:16
Last Modified: 19 Sep 2010 05:30
URI: http://eprints.iisc.ac.in/id/eprint/19861

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