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Structural basis for the function of anti-idiotypic antibody in immune memory

Vani, J and Chatterjee, Jhinuk and Shaila, MS and Nayak, R and Chandra, Nagasuma R (2009) Structural basis for the function of anti-idiotypic antibody in immune memory. In: Molecular Immunology, 46 (6). pp. 1250-1255.

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We had earlier proposed a hypothesis to explain the mechanism of perpetuation of immunological memory based on the operation of idiotypic network in the complete absence of antigen. Experimental evidences were provided for memory maintenance through anti-idiotypic antibody (Ab2) carrying the internal image of the antigen. In the present work, we describe a structural basis for such memory perpetuation by molecular modeling and structural analysis studies. A three-dimensional model of Ab2 was generated and the structure of the antigenic site on the hemagglutinin protein H of Rinderpest virus was modeled using the structural template of hemagglutinin protein of Measles virus. Our results show that a large portion of heavy chain containing the CDR regions of Ab2 resembles the domain of the hemagglutinin housing the epitope regions. The similarity demonstrates that an internal image of the H antigen is formed in Ab2, which provides a structural basis for functional mimicry demonstrated earlier. This work brings out the importance of the structural similarity between a domain of hemagglutinin protein to that of its corresponding Ab2. It provides evidence that Ab2 is indeed capable of functioning as surrogate antigen and provides support to earlier proposed relay hypothesis which has provided a mechanism for the maintenance of immunological memory.

Item Type: Journal Article
Publication: Molecular Immunology
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Anti-id antibody;Antigen; Molecular mimicry;In silico analysis;Immunological memory;Relay hypothesis
Department/Centre: Division of Information Sciences (Doesn't exist now) > BioInformatics Centre
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 15 Dec 2009 05:01
Last Modified: 19 Sep 2010 05:30
URI: http://eprints.iisc.ac.in/id/eprint/19826

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