Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1,2-Cyclopropane Carboxylated Sugar Derivatives

Haveli, SD and Roy, S and Chandrasekaran, Srinivasan (2009) Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1,2-Cyclopropane Carboxylated Sugar Derivatives. In: Synlett (3). pp. 451-455.

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Abstract

We have developed a general and efficient method for the stereoselective construction of pyrimidine-based pyranosyl C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2-cyclopropanated sugar derivatives. This methodology has been successfully extended to the synthesis of furanosyl nucleosides, Which have potential applications in the development of novel, nontoxic antifungal therapeutics.

Item Type:	Journal Article
Publication:	Synlett
Publisher:	Georg Thieme Verlag KG
Additional Information:	Copyright for this article belongs to Georg Thieme Verlag.
Keywords:	Uracil Polyoxin C; Organic-Synthesis; Nikkomycin-B; Saccharomyces-Cerevisiae; Antifungal Activity; Antibiotics; Cyclopropanes
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	03 Jan 2010 09:44
Last Modified:	19 Sep 2010 05:29
URI:	http://eprints.iisc.ac.in/id/eprint/19714

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