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Perpetuation of immunological memory: a relay hypothesis

Nayak, R and Mitra-Kaushik, S and Shaila, MS (2001) Perpetuation of immunological memory: a relay hypothesis. In: Immunology, 102 (4). pp. 387-395.


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A mechanism is proposed which explains the perpetuation of B-cell immunological memory indeÆnitely without requiring the presence of long-living memory cells or persisting antigen. The salient feature of this model is that immunological memory can be perpetuated indeÆnitely through the mutual interaction of idiotypic and anti-idiotypic B cells. These cells mutually stimulate and clonally expand with either speciÆc or bystander T-cell help. Because B cells can present antigen, they present `apparently foreign' idiopeptides to T cells. The idiopeptides of de novo synthesized antibody is presented to CD8+ T cells that recognize the idiopeptide-presenting cell as targets and regulate their population. The recycling of immunoglobulins from surface to endosomal compartment of B cells leads to the presentation of idiopeptides by major histocompatibility complex (MHC) class II to CD4+ T cells. Even if the majority of the clonally expanded cells die because of lack of stimulation, cytotoxic T lymphocyte (CTL) lysis or for other reasons, the surviving cells will be able to carry forward the memory. This mechanism also provides a means for afÆnity maturation through idiotypic selection of somatically mutated high afÆnity cells or those from the nai»ve pool. We have termed these two types of complementary B cells as Burnet B cells: those which recognize the antigen or antigen mimic, and Jerne B cells, which can recognize the idiotypes of antibody and carry antigen mimics. The proposed hypothesis can explain differential duration of memory for different antigens, the shelf space paradox, afÆnity maturation, repertoire shift, etc.

Item Type: Journal Article
Publication: Immunology
Publisher: Blackwell Science
Additional Information: Copyright for this article belongs to Blackwell Science.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 10 Sep 2004
Last Modified: 19 Sep 2010 04:16
URI: http://eprints.iisc.ac.in/id/eprint/1971

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