DC-SIGN and alpha 2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells

Bayry, Jagadeesh and Bansal, Kushagra and Kazatchkine, Michel D and Kaveri, Srini V (2009) DC-SIGN and alpha 2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells. In: Proceedings Of The National Academy Of Sciences Of The United States Of America, 106 (9). E24.

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Abstract

Intravenous immunoglobulin (IVIg) is widely used to treat autoimmune diseases. Several mutually nonexclusive mechanisms are proposed to explain the beneficial effects of IVIg in patients (1, 2). Lately, Ravetch and colleagues (3) demonstrate that anti-inflammatory activity of IVIg is mediated mainly by antibodies that contain terminal _2,6-sialic acid linkages at the Asn297-linked glycan of Fc region.

Item Type:	Journal Article
Publication:	Proceedings Of The National Academy Of Sciences Of The United States Of America
Publisher:	National Academy of Sciences
Additional Information:	Copyright of this article belongs toNational Academy of Sciences.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	03 Jul 2009 05:36
Last Modified:	19 Sep 2010 05:29
URI:	http://eprints.iisc.ac.in/id/eprint/19632

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