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B- and T-cell epitopes of tropomyosin, the major shrimp allergen

Subba Rao, PV and Rajagopal, D and Ganesh, KA (1998) B- and T-cell epitopes of tropomyosin, the major shrimp allergen. In: Allergy, 53 (46). pp. 44-47.

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Seafood allergy is often encountered on ingestion of crustaceans such as shrimp, lobster, crab, and crayfish (1). On eating cooked shrimp, sensitive individuals experience a wide spectrum of reactions ranging from abdominal discomfort to anaphylaxis. The presence of cross-reacting heat-stable allergens in crustacean food was first recognized by Hoffman et al. (2) and Lehrer et al. (3). Subsequently, the major allergen was isolated and characterized from the shrimp species Paneaus indicus (Pen i 1) (4) and I? aztecm (Pen a 1) (5). Pen i 1 (originally designated Sa-TI) and Pen a 1, with mol. mass of 34 and 36 kDa, respectively, contain 301 and 312 amino-acid residues with a predominance of gluta- mate/glutamine and asparatate/asparagine.

Item Type: Journal Article
Publication: Allergy
Publisher: Munksgaard
Additional Information: Copyright of this article belongs to Munksgaard.
Keywords: allergen;epitope;immunotherapy;seafood allergy;tropomyosin.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 22 Apr 2009 04:47
Last Modified: 19 Sep 2010 05:29
URI: http://eprints.iisc.ac.in/id/eprint/19591

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