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IFN-gamma inhibits growth of WISH cells in a cell cycle phase-specific manner

Supriya, P and Joshi, CV and Ajitkumar, P (1998) IFN-gamma inhibits growth of WISH cells in a cell cycle phase-specific manner. In: Journal of Interferon & Cytokine Research, 18 (04). pp. 215-217.

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Official URL: http://www.liebertonline.com/doi/abs/10.1089/jir.1...


Treatment of WISH (human amnion) cells with interferon-gamma (IFN-gamma) inhibits their growth. Release of the cells from IFN-gamma-mediated growth inhibition led to a rapid and significant increase in DNA synthesis, followed by doubling of cell numbers. The DNA synthesis profile was strikingly similar to that shown by WISH cells released from growth arrest by the G(1)/S phase inhibitor, aphidicolin, This strongly suggested that IFN-gamma treatment leads to growth inhibition of WISH cells at the G(1)/S boundary of the cell cycle. In contrast, IFN-alpha blocked growth of these cells at the G(0)/G(1) boundary.

Item Type: Journal Article
Publication: Journal of Interferon & Cytokine Research
Publisher: Mary Ann Liebert
Additional Information: Copyright of this article belongs to Mary Ann Liebert.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 17 Aug 2009 06:34
Last Modified: 17 Aug 2009 06:34
URI: http://eprints.iisc.ac.in/id/eprint/19507

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