Telomere structure, replication and length maintenance

Muniyappa‌, K and Mary Kironmai, K (1998) Telomere structure, replication and length maintenance. In: Critical Reviews in Biochemistry and Molecular Biology, 33 (04). pp. 297-336.

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Abstract

Telomeres are the termini of linear eukaryotic chromosomes consisting of tandem repeats of DNA and proteins that bind to these repeat sequences. Telomeres ensure the complete replication of chromosome ends, impart protection to ends from nucleolytic degradation, end-to-end fusion, and guide the localization of chromosomes within the nucleus. In addition, a combination of genetic, biochemical, and molecular biological approaches have implicated key roles for telomeres in diverse cellular processes such as regulation of gene expression, cell division, cell senescence, and cancer. This review focuses on recent advances in our understanding of the organization of telomeres, telomere replication, proteins that bind telomeric DNA, and the establishment of telomere length equilibrium.

Item Type:	Journal Article
Publication:	Critical Reviews in Biochemistry and Molecular Biology
Publisher:	Taylor and Francis Group
Additional Information:	Copyright of this article belongs to Taylor and Francis Group.
Keywords:	TG(1-3) repeats; subtelomeric elements; G4-quadruplex structures; telomere replication; telomerase RNA; telomere end-binding proteins;telomere position effect; transcriptional silencing;heterochromatin; recombinational repair;aging;cancer.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	17 Dec 2009 11:19
Last Modified:	19 Sep 2010 05:28
URI:	http://eprints.iisc.ac.in/id/eprint/19400

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