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Tyrosine phosphorylation of the human guanylyl cyclase C receptor

Bhandari, Rashna and Mathew, Roy and Vijayachandra, K and Visweswariah, Sandhya S (2000) Tyrosine phosphorylation of the human guanylyl cyclase C receptor. In: Journal Of Biosciences, 25 (4). pp. 339-346.


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Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Go-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCG) in Escherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GGC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.

Item Type: Journal Article
Publication: Journal Of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright for this article belongs to Indian Academy of Sciences.
Keywords: EphB1;guanylyl cyclase C;tyrosine phosphorylation
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 03 Sep 2004
Last Modified: 19 Sep 2010 04:16
URI: http://eprints.iisc.ac.in/id/eprint/1905

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