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Antimalarial Activities of Peptide Antibiotics Isolated from Fungi

Nagaraj, G and Uma, MV and Shivayogi, MS and Balaram, Hemalatha (2001) Antimalarial Activities of Peptide Antibiotics Isolated from Fungi. In: Antimicrobial Agents And Chemotherapy, 45 (1). pp. 145-149.


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Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of infections caused by drug resistant parasites. Secondary metabolites from fungi are an attractive source of chemotherapeutic agents. This work reports the isolation and in vitro antiplasmodial activities of peptide antibiotics of fungal origin. The three peptide antibiotics used in this study were efrapeptins, zervamicins, and antiamoebin. The high-performance liquid chromatography-purified peptides were characterized by nuclear magnetic resonance and mass spectral analysis. All three fungal peptides kill P. falciparum in culture with 50% inhibitory concentrations in the micromolar range. A possible mode of action of these peptide antibiotics on P. falciparum is presented

Item Type: Journal Article
Publication: Antimicrobial Agents And Chemotherapy
Publisher: American Society for Microbiology
Additional Information: The DOI is currently only displayed. Copyright for this article belongs to American Society for Microbiology.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 22 Aug 2008
Last Modified: 19 Sep 2010 04:16
URI: http://eprints.iisc.ac.in/id/eprint/1904

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