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Effect of calcium ion channel antagonists on chorionic gonadotropin secretion

Sharma, SC and Rao, AJ (1997) Effect of calcium ion channel antagonists on chorionic gonadotropin secretion. In: Biochemistry And Molecular Biology International, 43 (5). pp. 1101-1106.

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Official URL: http://www.ionchannels.org/showabstract.php?pmid=9...


By using calcium ion channel antagonists such as Verapamil and Nifedipine, we demonstrated that calcium ion channels are involved in human chorionic gonadotropin (hCG) secretion stimulated by gonadotropin releasing hormone (GnRH) Addition of 1 mu M Verapamil (Class II inhibitor) resulted in an inhibition of GnRH-stimulated hCG secretion by placenta without affecting basal release. However, while addition of 10 mu M Nifedipine (Class I inhibitor) resulted only in partial inhibition, significant inhibition was observed at 100 mu M concentration and above. These results suggest that calcium ion channels in placenta appear to be similar although not identical with the channels reported in the pituitary.

Item Type: Journal Article
Publication: Biochemistry And Molecular Biology International
Publisher: Academic Press
Additional Information: Copyright of this article belongs to Academic Press.
Keywords: Calcium ion channel;placenta;verapamil;nifedipine;hCG secretion.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 02 Jun 2009 05:11
Last Modified: 02 Jun 2009 05:11
URI: http://eprints.iisc.ac.in/id/eprint/18886

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