Balaji, KN and Nayak, R (1997) Effect of 5-Fluorouracil on Interleukin-1 and Interleukin-2 receptor expression. In: Biochemistry And Molecular Biology International, 42 (2). pp. 419-424.
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We have studied the effect of anticancer drug 5-Fluorouracil on the expression of human Interleukin-1 and Interleukin-2 receptor. In this report, we show that 5-fluorouracil increases the Interleukin-l expression upto 2.66 folds without significantly affecting the levels of surface expression of p55 IL-2 receptor on human Peripheral blood mononuclear cells, CD4 and CD8 T cells. On contrary, the drug decreases the levels of Interferon-gamma secretion by upto 42%. In earlier studies we have shown that 5-Fluorouracil increases the IL-2 expression both at mRNA and protein levels. Taken together, 5-Fluorouracil differentially affects the expression of Interleukin-1, Interferon-gamma and Interleukin-2 receptor.
| Item Type: | Journal Article |
|---|---|
| Publication: | Biochemistry And Molecular Biology International |
| Publisher: | Academic Press |
| Additional Information: | Copyright of this article belongs to Biochemistry And Molecular Biology International. |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 02 Jun 2009 05:07 |
| Last Modified: | 02 Jun 2009 05:07 |
| URI: | http://eprints.iisc.ac.in/id/eprint/18884 |
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