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Effect of 5-Fluorouracil on Interleukin-1 and Interleukin-2 receptor expression

Balaji, KN and Nayak, R (1997) Effect of 5-Fluorouracil on Interleukin-1 and Interleukin-2 receptor expression. In: Biochemistry And Molecular Biology International, 42 (2). pp. 419-424.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/9238541


We have studied the effect of anticancer drug 5-Fluorouracil on the expression of human Interleukin-1 and Interleukin-2 receptor. In this report, we show that 5-fluorouracil increases the Interleukin-l expression upto 2.66 folds without significantly affecting the levels of surface expression of p55 IL-2 receptor on human Peripheral blood mononuclear cells, CD4 and CD8 T cells. On contrary, the drug decreases the levels of Interferon-gamma secretion by upto 42%. In earlier studies we have shown that 5-Fluorouracil increases the IL-2 expression both at mRNA and protein levels. Taken together, 5-Fluorouracil differentially affects the expression of Interleukin-1, Interferon-gamma and Interleukin-2 receptor.

Item Type: Journal Article
Publication: Biochemistry And Molecular Biology International
Publisher: Academic Press
Additional Information: Copyright of this article belongs to Biochemistry And Molecular Biology International.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 02 Jun 2009 05:07
Last Modified: 02 Jun 2009 05:07
URI: http://eprints.iisc.ac.in/id/eprint/18884

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