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Decavanadate possesses \alpha-adrenergic agonist activity and a structural motif common with trans- \beta form of noradrenaline

Venkataraman, BV and Ravishankar, HN and Rao, AVS and Kalyani, P and Sharada, G and Namboodiri, K and Gabor, B and Ramasarma, T (1997) Decavanadate possesses \alpha-adrenergic agonist activity and a structural motif common with trans- \beta form of noradrenaline. In: Molecular and Cellular Biochemistry, 169 (1-2). pp. 27-36.

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Decavanadate, an inorganic polymer of vanadate, produced contraction of rat aortic rings at a relatively high concentration compared to phenylephrine, an agonist of alpha-adrenergic receptor. This effect was blocked by two known alpha-adrenergic receptor antagonists, prazosin and phenoxybenzamine. Decavanadate, formed by possible dimerization of V-5 under acid conditions, possessed a structural feature of two pairs of unshared oxygen atoms at a distance of 3.12 Angstrom, not found in its constituents of V-4 or V-5. A structural motif of O..O..O using such oxygen atoms is recognized in decavanadate. This matches with a similar motif of N..O..O that uses the essential amino and hydroxyl groups of the side-chain and the m-hydroxyl group in trans-beta form of noradrenaline. The interaction of such a structural motif with the membrane receptor is likely to be the basis of the unusual noradrenaline-mimic action of decavanadate.

Item Type: Journal Article
Publication: Molecular and Cellular Biochemistry
Publisher: Springer
Additional Information: Copyright of this article belongs to Kluwer Academic Publishers.
Keywords: Decavanadate;alpha-adrenergic receptor;noradrenaline;aortic contraction.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 18 Mar 2009 05:09
Last Modified: 19 Sep 2010 05:25
URI: http://eprints.iisc.ac.in/id/eprint/18789

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