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Molecular toxicity of aluminium in relation to neurodegeneration

Vasudevaraju, Bharathi P and Govindaraju, M and Palanisamy, AP and Sambamurti, K and Rao, KSJ (2008) Molecular toxicity of aluminium in relation to neurodegeneration. In: Indian Journal of Medical Research, 128 (04). pp. 545-556.

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Exposure to high levels of aluminium (Al) leads to neurofibrillary degeneration and that At concentration is increased in degenerating neurons in Alzheimer's disease (AD). Nevertheless, the role of Al in AD remains controversial and there is little proof directly interlinking Al to AD. The major problem in understanding Al toxicity is the complex At speciation chemistry in biological systems. A new dimension is provided to show that Al-maltolate treated aged rabbits can be used as a suitable animal model for understanding the pathology in AD. The intracisternal injection of At-maltolate into aged New Zealand white rabbits results in pathology that mimics several of the neuropathological, biochemical and behavioural changes as observed in AD. The neurodegenerative effects include the formation of intraneuronal neurofilamentous aggregates that are tau positive, oxidative stress and apoptosis. The present review discusses the role of Al and use of Al-treated aged rabbit as a suitable animal model to understand AD pathogenesis.

Item Type: Journal Article
Publication: Indian Journal of Medical Research
Publisher: Indian Council of Medical Research
Additional Information: Copyright of this article belongs to Indian Council of Medical Research.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 25 Nov 2009 08:28
Last Modified: 19 Sep 2010 05:25
URI: http://eprints.iisc.ac.in/id/eprint/18738

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