CpG Islands in Chromatin Organization and Gene Expression

Kundu, Tapas K and Rao, MRS (1999) CpG Islands in Chromatin Organization and Gene Expression. In: Journal of Biochemistry, 125 (2). pp. 217-222.

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Abstract

CpG islands are stretches of DNA sequence that are enriched in the (CpG)(n) repeat and are present in close association with all housekeeping genes as well as some tissue-specific genes in the mammalian genome. Methylation of CpG islands strongly influences both structural organization and function of chromatin. The presence of a CpG island in a given chromosomal domain can, by itself, give rise to relatively open and active chromatin, Recently, several histone acetyltransferases, histone deacetylases, and chromatin remodeling factors have been found to be part of the transcription machinery. It is becoming increasingly clear that CpG islands and their methylation status may influence the function or recruitment of these newly discovered chromatin remodeling factors, especially the histone deacetylases. In addition, CpG islands may also play a significant role in the reorganization of chromatin during mammalian spermiogenesis.

Item Type:	Journal Article
Publication:	Journal of Biochemistry
Publisher:	Japanese Biochemical Society
Additional Information:	Copyright of this article belongs to Japanese Biochemical Society.
Keywords:	Chromatin remodeling;DNA methylation;Histone acetylation and deacetylation;Spermiogenesis;Transition proteins.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	05 Mar 2009 06:03
Last Modified:	19 Sep 2010 05:01
URI:	http://eprints.iisc.ac.in/id/eprint/18279

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