Chronic (-) deprenyl administration increases dendritic arborization in CA3 neurons of hippocampus and AChE activity in specific regions of the primate brain

Lakshmana, Madepalli K and Rao, BS Shankaranarayana and Dhingra, Narender K and Ravikumar, R and Govindaiah, * and Ramachandra, * and Metia, BL and Raju, TR (1998) Chronic (-) deprenyl administration increases dendritic arborization in CA3 neurons of hippocampus and AChE activity in specific regions of the primate brain. In: Brain Research, 796 (1-2). pp. 38-44.

PDF Chronic.pdf - Published Version Restricted to Registered users only Download (82kB) | Request a copy

Abstract

The mechanism by which (-) deprenyl enhances cognitive function in Alzheimer's disease (AD) is not yet understood. (-) Deprenyl (0.2 mg/kg/day) was administered intramuscularly to adult male monkeys (n = 6) for 25 days. Control monkeys (n = 6) received physiological saline by the same route. The activity of acetylcholinesterase (AChE) in different brain regions and the dendritic arborization in CA3 pyramidal neurons of hippocampus were analysed, (-) Deprenyl-treated monkeys showed a significant increase in the AChE activity by 43% (p < 0.001) in the frontal cortex, by 39% (p < 0.025) in the motor cortex, by 66% (p < 0.001) in the hippocampus and by 26% (p < 0.05) in the striatum compared to controls. The branching points and the intersections of both apical and basal dendrites of CA3 hippocampal pyramidal neurons were also significantly increased in (-) deprenyl-treated monkeys. Enhanced AChE activity may increase dendritic arborization in the hippocampus and it may also play a role in improving cognitive functions observed in AD, following(-) deprenyl treatment.

Item Type:	Journal Article
Publication:	Brain Research
Publisher:	Elsevier Science
Additional Information:	copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Centre for Neuroscience
Date Deposited:	13 Mar 2009 07:07
Last Modified:	14 Nov 2018 15:12
URI:	http://eprints.iisc.ac.in/id/eprint/18234

Actions (login required)

View Item