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His kinase or mine? Histidine kinases through evolution

Shenoy, Avinash R (2000) His kinase or mine? Histidine kinases through evolution. In: Journal of Biosciences, 25 (04). pp. 317-322.

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Sensing environmental changes and responding to them is the key to any organism’s survival. The simplest example of a sensor-response system is seen in bacteria in the form of what is known as the two-component system. This system involves proteins in which the sensor or component I detects the stimulus via its input or sensor domain and is trans-autophosphorylated on a conserved histidine. The sensor then transfers this phosphate to the response regulator, or component II, on a conserved aspartic acid residue (Hoch 2000).This His-Asp signal transduction pathway, though ubiquitous in prokaryotes, is rarely encountered in higher eukaryotes.

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 01 Sep 2009 06:44
Last Modified: 19 Sep 2010 04:58
URI: http://eprints.iisc.ac.in/id/eprint/17793

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