Shenoy, Avinash R (2000) His kinase or mine? Histidine kinases through evolution. In: Journal of Biosciences, 25 (04). pp. 317-322.
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Abstract
Sensing environmental changes and responding to them is the key to any organism’s survival. The simplest example of a sensor-response system is seen in bacteria in the form of what is known as the two-component system. This system involves proteins in which the sensor or component I detects the stimulus via its input or sensor domain and is trans-autophosphorylated on a conserved histidine. The sensor then transfers this phosphate to the response regulator, or component II, on a conserved aspartic acid residue (Hoch 2000).This His-Asp signal transduction pathway, though ubiquitous in prokaryotes, is rarely encountered in higher eukaryotes.
Item Type: | Journal Article |
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Publication: | Journal of Biosciences |
Publisher: | Indian Academy of Sciences |
Additional Information: | Copyright of this article belongs to Indian Academy of Sciences. |
Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
Date Deposited: | 01 Sep 2009 06:44 |
Last Modified: | 19 Sep 2010 04:58 |
URI: | http://eprints.iisc.ac.in/id/eprint/17793 |
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