Toward a total synthesis of the novel neurotrophic sesquiterpene merrilactone A: a RCM and [2+2]-photocycloaddition based approach to framework construction

Mehta, Goverdhan and Singh, Robindro S (2005) Toward a total synthesis of the novel neurotrophic sesquiterpene merrilactone A: a RCM and [2+2]-photocycloaddition based approach to framework construction. In: Tetrahedron Letters, 46 (12). pp. 2079-2082.

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Abstract

A new strategy toward the total synthesis of the novel structural complex and biologically potent neurotrophic factor merrilactone A from 2,3-dimethyl-2-cyclopentene-1,4-dione is outlined. The approach involving RCM and [2+2]-photocycloaddition as the key steps, is notable for the orchestration of a series of regio- and stercoselective operations that lead to the core structural motif present in the sesquiterpenoid natural product. (C) 2005 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	09 Feb 2010 10:45
Last Modified:	19 Sep 2010 04:56
URI:	http://eprints.iisc.ac.in/id/eprint/17416

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