Bindu, R and Venkataraman, BV and Rao, Aparna VS and Ramasarma, T (2003) Relaxation of arterial smooth muscle: A new function of a water-soluble degradation product of coenzyme Q (ubiquinone). In: BioFactors, 18 (1-4). pp. 137-143.
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Abstract
Treatment of coenzyme Q with ozone yielded a degradation product having unmodified ring that retained its spectral characteristics and a truncated side-chain that made it water-soluble. This derivative, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. This effect offers an explanation for the known hypotensive action of exogenous coenzyme Q regardless of its side-chain length.
Item Type: | Journal Article |
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Publication: | BioFactors |
Publisher: | IOS Press |
Additional Information: | Copyright of this article belongs to IOS Press. |
Keywords: | coenzyme Q;ubiquinone;relaxation of arterial rings;water-soluble degradation product;BP lowering effect. |
Department/Centre: | Division of Chemical Sciences > Solid State & Structural Chemistry Unit Division of Biological Sciences > Biochemistry |
Date Deposited: | 31 Oct 2009 08:46 |
Last Modified: | 31 Oct 2009 08:46 |
URI: | http://eprints.iisc.ac.in/id/eprint/17303 |
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