Optimization of fed-batch bioreactor for immobilized enzyme processes

Sengupta, S and Modak, JM (2001) Optimization of fed-batch bioreactor for immobilized enzyme processes. In: Chemical Engineering Science, 56 (11). pp. 3315-3325.

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Abstract

A systematic analysis of the problem of determining optimal feeding strategies for immobilized enzyme reactions in fed batch bioreactor is presented in this paper. The optimal control theory is applied to a heterogeneous bioreactor model consisting of a bulk liquid phase and an immobilized enzyme phase. The optimal feeding policy and singular interval are obtained in terms of state variables alone. It is shown that a constantly fed bioreactor operation is optimal for a process whose kinetics depends on the single reactant concentration. The analytical results are supplemented with a numerical example of deacylation of penicillin G. Effects of various operating conditions, such as reactant feed concentration, enzyme loading and diffusional limitation, on the optimal performance of the bioreactor is illustrated.

Item Type:	Journal Article
Publication:	Chemical Engineering Science
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Ioreactors;diffusion;enzyme;fed-batch;immobilization;optimization
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	04 Feb 2010 10:33
Last Modified:	19 Sep 2010 04:55
URI:	http://eprints.iisc.ac.in/id/eprint/17184

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