Booster immunization of antigen primed mice with anti-idiotypic T cells generates antigen-specific memory T cell response

Lal, Girdhari and Shaila, MS and Nayak, Rabindranath (2006) Booster immunization of antigen primed mice with anti-idiotypic T cells generates antigen-specific memory T cell response. In: Vaccine, 24 (8). 1149 -1158.

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Abstract

Immunological memory is characterized by quick and enhanced immune response after re-exposure to the same antigen. In the present work, we have shown that anti-idiotypic T cells are generated in mice after immunization with idiotypic T cell clone or polyclonal T cell specific for nucleocapsid protein of Rinderpest virus. Further, we have shown that N specific idiotypic T cell receptors from apoptotic idiotypic T cells are processed by bone marrow derived dendritic cells and presented to cognate anti-idiotypic T cells. Evidence has been provided for the existence of antigen specific T cell idiotypic network in the body. Boosting with antigen specific anti-idiotypic T cells generates memory response in the antigen-primed mice

Item Type:	Journal Article
Publication:	Vaccine
Publisher:	Elsavier
Additional Information:	Copyright of this article belongs to Elsavier
Keywords:	Immunology;Medicine, Research & Experimental;Veterinary Sciences;Myelin-Basic-Protein;Mhc Class-Ii;Experimental Autoimmune Encephalomyelitis;Newly Synthesized Proteins; Apoptotic Cells;In-Vivo;Multiple-Sclerosis;Nucleocapsid Protein;Immunological Memory;Rinderpest Virus;T cell memory;anti-idiotypic T cells;idiopeptide;peptidomimics; relay hypothesis
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	08 Dec 2008 12:22
Last Modified:	19 Sep 2010 04:54
URI:	http://eprints.iisc.ac.in/id/eprint/16917

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