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sY116, a human Y-linked polymorphic STS

Saifi, Mustafa G and Veitia, Reiner and El khil, Houssein Khodjet and Barbaux, Sandrine and Tilak, Preetha and Thomas, Manorama I and Fellous, Marc (2000) sY116, a human Y-linked polymorphic STS. In: Journal of Genetics, 79 (1). pp. 17-20.


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During a study of deletions of Y-chromosomal DNA in infertile males, sY116, a Y-linked STS, showed different electrophoretic mobilities in three males, two infertile and one fertile. A study of this STS among 35 other normal males showed that this locus is polymorphic. sY116 has a polya-rich stretch whose instability appears to be the most likely cause of this polymorphism. The possible usefulness of sY116 polymorphism in the detection of subtle genome-wide instabilities in some types of cancer is discussed.

Item Type: Journal Article
Publication: Journal of Genetics
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: male infertility;polymorphism;Y chromosome;mitotic instability.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 30 Sep 2004
Last Modified: 19 Sep 2010 04:15
URI: http://eprints.iisc.ac.in/id/eprint/1689

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