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Basal transcription machinery: role in regulation of stress response in eukaryotes

Sadhale, Parag and Verma, Jiyoti and Naorem, Aruna (2007) Basal transcription machinery: role in regulation of stress response in eukaryotes. In: Journal of Biosciences, 32 (3). pp. 569-578.

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The holoenzyme of prokaryotic RNA polymerase consists of the core enzyme, made of two alpha, beta, beta' and omega subunits, which lacks promoter selectivity and a sigma (sigma) subunit which enables the core enzyme to initiate transcription in a promoter dependent fashion. A stress sigma factor sigma(s), in prokaryotes seems to regulate several stress response genes in conjunction with other stress specific regulators. Since the basic principles of transcription are conserved from simple bacteria to multicellular complex organisms, an obvious question is: what is the identity of a counterpart of as, that is closest to the core polymerase and that dictates transcription of stress regulated genes in general? In this review, we discuss the logic behind the suggestion that like in prokaryotes, eukaryotes also have a common functional unit in the transcription machinery through which the stress specific transcription factors regulate rapid and highly controlled induction of gene expression associated with generalized stress response and point to some candidates that would fit the bill of the eukaryotic sigma(s).

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Springer
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Basal transcription;eukaryotes;stress response
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 05 Dec 2008 07:32
Last Modified: 19 Sep 2010 04:54
URI: http://eprints.iisc.ac.in/id/eprint/16848

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