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Conformation of gramicidin-A in CTAB micellar media

Shobini, J and Mishra, AK and Chandra, Nagasuma (2003) Conformation of gramicidin-A in CTAB micellar media. In: Journal of Photochemistry and Photobiology B: Biology, 70 (2). pp. 117-124.

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Gramicidin A (gA) is a linear pentadecapeptide, which exhibits various conformations depending on the environment. The conformational behavior of gA in spherical and rod-shaped cationic micelles formed by cetyltrimethylammonium bromide (CTAB) surfactant has been studied using circular dichroism (CD) and fluorescence spectroscopy, and a probable structure of gramicidin A in CTAB media has been proposed. A CD study shows that gramicidin A assumes$\beta^{ 6.3}$ helical structure in cationic spherical as well as rod-shaped CTAB micellar media. Modeling studies show the flexibility of the side chain conformation particularly in tryptophan-9. Study of intrinsic fluorescence of tryptophans in gramicidin A indicates three distinct environments for the four-tryptophan

Item Type: Journal Article
Publication: Journal of Photochemistry and Photobiology B: Biology
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Gramicidin A;Fluorescence spectroscopy;Circular dichroism; Model
Department/Centre: Division of Information Sciences (Doesn't exist now) > BioInformatics Centre
Date Deposited: 17 Dec 2008 05:14
Last Modified: 19 Sep 2010 04:53
URI: http://eprints.iisc.ac.in/id/eprint/16676

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