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Production of Penicillin

Rao, Srinivasa S (1944) Production of Penicillin. In: Nature, 154 (3898). p. 83.

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THE usual method adopted in the large-scale production of penicillin is to grow Penicillium notatum on shallow layers of modified Czapek-Dox media1 at $24^o C$. for 10–12 days. The metabolic solution at the end of the incubation period has an activity of 3–4 'Oxford' units per c.c. This process involves handling large volumes of solution, and the space required is enormous. Moreover, the danger of contamination by penicillin-destroying bacteria during the lengthy incubation period is obvious.

Item Type: Journal Article
Publication: Nature
Publisher: Nature Publishing Group
Additional Information: Copyright for this article belongs to Nature Publishing Group.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 20 Oct 2008 07:37
Last Modified: 19 Sep 2010 04:51
URI: http://eprints.iisc.ac.in/id/eprint/16340

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