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Inhibition of in Vitro Amino Acylation and Translation by Adenosine Antibodies

Vaishnav, YN and Antony, A (1988) Inhibition of in Vitro Amino Acylation and Translation by Adenosine Antibodies. In: Biochemical and Biophysical Research Communications, 155 (3). pp. 1381-1386.

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Adenosine antibodies markedly inhibited in vitro amino acylation of tRNA in a dose-dependent manner. The inhibition was specific as it was reversed by the homologous hapten. Addition of excess tRNA reversed the inhibition indicating that binding of antibodies to tRNA is responsible for inhibition. Adenosine antibodies also inhibited in vitro translation of endogenous mRNAs in rabbit reticulocyte lysate in a dose-dependent manner. The homologous hapten reversed the inhibition showing thereby the immunospecificity of inhibition.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier
Additional Information: Copyright for this article belongs to Elsevier.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 25 Aug 2008
Last Modified: 19 Sep 2010 04:49
URI: http://eprints.iisc.ac.in/id/eprint/15615

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