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Cytochrome P-450 in drug-resistant Mycobacterium tuberculosis

Ramachandran, Geetha and Gurumurthy, Prema and Narayanan, PR and Mahadevan, Usha (1999) Cytochrome P-450 in drug-resistant Mycobacterium tuberculosis. In: Current Science, 76 (9). pp. 1231-1234.


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Methods for the isolation and spectrophotometric determination of cytochrome P-450 in mycobacteria were standardized. Cytochrome P-450 levels were estimated in Mycobacterium tuberculosis organisms sensitive to both isoniazid and rifampicin and resistant to any of the two drugs. Cytochrome P- 450 was isolated and its presence was shown in M. smegmatis, M. fortuitum, M. chelonae and M. tuberculosis H(37)Rv. The cytochrome P-450 content was significantly elevated in M. tuberculosis, resistant to both isoniazid and rifampicin when compared with the corresponding sensitive strains. It therefore appears that cytochrome P-450 might play a role in causing drug resistance in tuberculosis.

Item Type: Journal Article
Publication: Current Science
Publisher: Indian Academy of Science
Additional Information: The copyright belongs to Indian Academy of Science.
Keywords: Mycobacterium tuberculosis;spectrophotometric determination;tuberculosis organisms;cytochrome P 450
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 01 Apr 2005
Last Modified: 19 Sep 2010 04:15
URI: http://eprints.iisc.ac.in/id/eprint/1557

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