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The fusion protein of peste des petits ruminants virus is a hemolysin

Devireddy, LR and Raghavan, R and Ramachandran, S and Shaila, MS (1999) The fusion protein of peste des petits ruminants virus is a hemolysin. In: Archives Of Virology, 144 (6). pp. 1241-1247.


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The fusion glycoprotein (F protein) of paramyxoviruses plays a vital role in virus-induced cytopathology. To explore the role of the F protein in peste des petits ruminants virus (PPRV)- induced cytopathology, the F protein of PPRV was purified by immunoaffinity chromatography. The purified F protein, when incubated with chicken erythrocytes, caused lysis suggesting that PPRV F protein is a hemolysin. Furthermore, the hemolysis can be inhibited by hyperimmune serum against F protein. The virus-induced cell fusion (syncytia) was also inhibited by the hyperimmune serum against the F protein. In summary, these results indicate that the purified PPRV F protein is biologically active and is involved in virus-induced hemolysis, cell-fusion and the initiation of infection.

Item Type: Journal Article
Publication: Archives Of Virology
Publisher: Springer Verlag Wien
Additional Information: The copyright belongs to Springer Verlag.
Keywords: fusion protein;petits ruminants virus;hemolysin;immunoaffinity chromatography
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 18 Mar 2005
Last Modified: 19 Sep 2010 04:15
URI: http://eprints.iisc.ac.in/id/eprint/1547

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