Metabolism of 1,8-Cineole in Rat: Its Effects on Liver and Lung Microsomal Cytochrome P-450 Systems

Madyastha, Madhava K and Chadha, Anju (1986) Metabolism of 1,8-Cineole in Rat: Its Effects on Liver and Lung Microsomal Cytochrome P-450 Systems. In: Bulletin of Environmental Contamination and Toxicology, 37 (1). pp. 759-766.

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Abstract

The monoterpene cyclic ether, cineole (l,8-cineole, I)also known as eucalyptol, is a component of many essential oils and is widely distributed in nature. It is extensively used in pharmaceutical preparations for external application and also as a nasal spray. It was reported earlier that cineole when administered to sheep may be largely oxidized in the system (Scheline 1978). However the mode of metabolism of cineole is not known. Hence the present study was undertaken to investigate the metabolic fate of this ubiquitous ter-penoid following its administration to rats by gastric intubation.

Item Type:	Journal Article
Publication:	Bulletin of Environmental Contamination and Toxicology
Publisher:	Springer
Additional Information:	Copyright for this article beongs to Springer.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	29 Jul 2008
Last Modified:	19 Sep 2010 04:48
URI:	http://eprints.iisc.ac.in/id/eprint/15333

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