Structure-Activity Investigation on the Gene Transfection Properties of Cardiolipin Mimicking Gemini Lipid Analogues

Bajaj, Avinash and Paul, Bishwajit and Kondaiah, Paturu and Bhattacharya, Santanu (2008) Structure-Activity Investigation on the Gene Transfection Properties of Cardiolipin Mimicking Gemini Lipid Analogues. In: Bioconjugate Chemistry, 19 (6). pp. 1283-1300.

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Abstract

A structure-activity relationship has been explored on the gene transfection efficiencies of cardiolipin mimicking gemini lipid analogues upon variation of length and hydrophilicity of the spacer between the cationic ammonium headgroups and lipid hydrocarbon chain lengths. All the gemini lipids were found to be highly superior in gene transfer abilities as compared to their monomeric lipid and a related commercially available formulation.Pseudoglyceryl gemini lipids bearing an oxyethylene $(-CH_2-(CH_2-O-CH_2) m-CH_2-)$ spacer were found to be superior gene transfecting agents as compared to those bearing polymethylene $(-CH_2)_m-)$ spacers. The major characteristic feature of the present set of gemini lipids is their serum compatibility, which is most often the major hurdle in liposome-mediated gene delivery.

Item Type:	Journal Article
Publication:	Bioconjugate Chemistry
Publisher:	Amerian Physical Society
Additional Information:	Copyright of this article belongs to Amerian Physical Society.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Chemical Sciences > Organic Chemistry
Date Deposited:	18 Jul 2008
Last Modified:	19 Sep 2010 04:47
URI:	http://eprints.iisc.ac.in/id/eprint/15093

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