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Novel chalcogenides of thymidine and uridine: synthesis, properties and applications

Sivapriya, Kirubakaran and Suguna, Perumal and Shubashree, S and Sridhar, Perali Ramu and Chandrasekaran, Srinivasan (2007) Novel chalcogenides of thymidine and uridine: synthesis, properties and applications. In: Carbohydrate Research, 342 (9). pp. 1151-1158.

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A facile and efficient methodology has been developed for the synthesis of dithymidine and di-uridine derived disulfides using benzyltriethylammonium tetrathiomolybdate as a sulfur transfer reagent. However, a similar reaction of thymidine derivative with tetraethylammonium tetraselenotungstate as a selenium transfer reagent resulted in the formation of an unexpected cyclic diselenide. The disulfide derivatives of nucleosides have been used as precursors in a tandem disulfide cleavage-Michael addition/ring opening reactions to construct aminoacid and carbocyclic derivatives of nucleosides.

Item Type: Journal Article
Publication: Carbohydrate Research
Publisher: Elsevier
Additional Information: Copyright of this article belongs to Elsevier.
Keywords: Nucleosides;Tetrathiomolybdate;Tetraselenotungstate;X-ray crystallography
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 08 Jul 2008
Last Modified: 19 Sep 2010 04:46
URI: http://eprints.iisc.ac.in/id/eprint/14778

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