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Noradrenaline treatment of rats stimulates $H_2O_2$ generation in liver mitochondria.

Swaroop, Anand and Patole, Milind S and Puranam, Ram S and Ramasarma, T (1983) Noradrenaline treatment of rats stimulates $H_2O_2$ generation in liver mitochondria. In: Biochemical Journal, 214 (3). pp. 745-750.

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Treatment of rats with noradrenaline stimulated $H_20_2$ generation in liver mitochondria using succinate, choline or glycerol 1-phosphate as substrate. The dehydrogenase activity with either succinate or choline as substrate showed no change, whereas that with glycerol 1-phosphate increased. 2. The effect was obtained with noradrenaline, but not with dihydroxyphenylserine. 3. Phenoxybenzamine and yohimbine, but not propranolol, prevented the response to noradrenaline treatment. 4. Phenylephrine could stimulate $H_20_2$ generation, whereas isoprenaline had only a marginal effect. 5. Theophylline treatment slightly decreased the generation of $H_20_2$ in liver mitochondria, but treatment with pargyline, Ro4-1284 and dibutyryl cyclic AMP had little effect. 6. These studies showed that noradrenaline might possibly be acting through the $\alpha_2$-adrenergic system.

Item Type: Journal Article
Publication: Biochemical Journal
Publisher: Portland Press
Additional Information: Copyright of this article belongs to Portland Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 04 Jul 2008
Last Modified: 19 Sep 2010 04:46
URI: http://eprints.iisc.ac.in/id/eprint/14774

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