Swaroop, Anand and Patole, Milind S and Puranam, Ram S and Ramasarma, T (1983) Noradrenaline treatment of rats stimulates $H_2O_2$ generation in liver mitochondria. In: Biochemical Journal, 214 (3). pp. 745-750.
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Abstract
Treatment of rats with noradrenaline stimulated $H_20_2$ generation in liver mitochondria using succinate, choline or glycerol 1-phosphate as substrate. The dehydrogenase activity with either succinate or choline as substrate showed no change, whereas that with glycerol 1-phosphate increased. 2. The effect was obtained with noradrenaline, but not with dihydroxyphenylserine. 3. Phenoxybenzamine and yohimbine, but not propranolol, prevented the response to noradrenaline treatment. 4. Phenylephrine could stimulate $H_20_2$ generation, whereas isoprenaline had only a marginal effect. 5. Theophylline treatment slightly decreased the generation of $H_20_2$ in liver mitochondria, but treatment with pargyline, Ro4-1284 and dibutyryl cyclic AMP had little effect. 6. These studies showed that noradrenaline might possibly be acting through the $\alpha_2$-adrenergic system.
Item Type: | Journal Article |
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Publication: | Biochemical Journal |
Publisher: | Portland Press |
Additional Information: | Copyright of this article belongs to Portland Press. |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 04 Jul 2008 |
Last Modified: | 19 Sep 2010 04:46 |
URI: | http://eprints.iisc.ac.in/id/eprint/14774 |
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