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Stabilization of $\beta$ -turn conformations in enkephalins. $\alpha$ -Aminoisobutyric acid analogs

Sudha, TS and Balaram, P (1983) Stabilization of $\beta$ -turn conformations in enkephalins. $\alpha$ -Aminoisobutyric acid analogs. In: International Journal of Peptide & Protein Research, 21 (4). pp. 381-388.


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Stereochemistry constraints were introduced into the enkephalin backbone by substituting $\alpha$-aminoisobutyryl (Aib) residues at positions 2 and 3, instead of Gly. 1H NMR studies of Tyr-Aib-Gly-Phe-Met-NH2 [69872-68-0], Tyr-Aib-Aib-Phe-Met-$NH_2$ [72564-51-3], and Tyr-Gly-Aib-Phe-Met-$NH_2$ [72564-52-4] demonstrate the occurrence of folded, intramolecularly H-bonded structures in org. solvents. Similar conformations are also favored in the corresponding tert-butyloxycarbonyl-protected tetrapeptides, which lack the Tyr residue. A $\beta$-turn centered at positions 2 and 3 is proposed for the $Aib_2-Gly_3$ analog. In the Gly2-Aib3 analog, the $\beta$-turn has $Aib_3-Phe_4$ as the corner residues. The $Aib_2-Aib_3$ analog adopts a consecutive $\beta$-turn or 310 helical conformation. High in vivo biol. activity is observed for the $Aib_2$ and $Aib_2-Aib_3$ analogs, while the $Aib_3$ peptide is less active

Item Type: Journal Article
Publication: International Journal of Peptide & Protein Research
Publisher: Copenhagen : Munksgaard
Additional Information: Copyright of this article belongs to Copenhagen:Munksgaard
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 24 Jun 2008
Last Modified: 19 Sep 2010 04:46
URI: http://eprints.iisc.ac.in/id/eprint/14406

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