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Mechanism of coupling periodate-oxidized nucleosides to proteins

Periannan, Senapathy and Mir, Ahmed A and Jacob, Mathai T (1985) Mechanism of coupling periodate-oxidized nucleosides to proteins. In: FEBS Letters, 190 (2). pp. 337-341.


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This paper describes a mechanism of coupling periodate-oxidized nucleosides to proteins. Each of the dialdehyde groups of a periodate-oxidized nucleoside is shown to couple to lysine residues on different protein molecules through Schiff bases, thereby cross-linking different protein molecules, forming a polymer. This is in contrast to the previous model in which nuclqosides were suggested to couple to proteins through a morpholine structure. The cross-linked structure of the nucleoside-antigen, significantly different when compared to the native protein, may affect the specificity and the efficiency of antibody production.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science
Additional Information: Copyright belongs to Elsevier Science
Keywords: Nucleoside-antigen Periodate oxidation Schiff base Protein cross-linking Polymerization;Antibody production
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Jun 2008
Last Modified: 19 Sep 2010 04:45
URI: http://eprints.iisc.ac.in/id/eprint/14281

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