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Metabolism of \beta-myrcene in vivo and in vitro: its effects on rat-liver microsomal enzymes

Madyastha, Madhava K and Srivatsan, V (1987) Metabolism of \beta-myrcene in vivo and in vitro: its effects on rat-liver microsomal enzymes. In: Xenobiotica, 17 (5). pp. 539-549.

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1. Metabolites isolated from the urine of rats after oral administration of β-myrcene (I) were: 10-hydroxylinalool (II), 7-methyl-3-methylene-oct-6-ene-1,2-diol (IV), 1-hydroxymethyl-4-isopropenyl cyclohexanol (VI), 10-carboxylinalool (III) and 2-hydroxy-7-methyl-3-methylene-oct-6-enoic acid (V). 2. Liver microsomes prepared from phenobarbital-treated rats convert β-myrcene (I) to 10-hydroxylinalool (II) in the presence of NADPH and oxygen. NADH neither supported this reaction nor did it show any synergistic effect. The rate of conversion was significantly greater in microsomes prepared from phenobarbital-treated rats than from 3-methylcholanthrene-treated or control microsomal preparations. The formation of 10-hydroxylinalool (II) was inhibited by metyrapone, carbon monoxide, SKF-525A, p-chloromercuric benzoate (\rho-CMB) and cytochrome c. 3. Titration of phenobarbital-induced liver microsomes with \beta -myrcene (I) produced a series of type I difference spectra with peaks around 387-390 nm and troughs around 421-425 nm. The {K_s} for \beta-myrcene was 10.6 \mu M. 4. Administration (four days) of \beta -myrcene (I) to rats did not result in any significant effect on the hepatic drug-metabolizing enzymes.

Item Type: Journal Article
Publication: Xenobiotica
Publisher: Taylor and Francis
Additional Information: Copyright for this article belongs to the Taylor and Francis
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 09 May 2008
Last Modified: 27 Aug 2008 13:21
URI: http://eprints.iisc.ac.in/id/eprint/13897

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