Rajagopal, Malini and Rao, Kekambareswara and Ayyer, Jayalekshmy and Sasisekharan, V (1987) Synthesis of a distamycin analog: tris(m-benzamido) compound. In: Indian Journal of Chemistry, Sect. B: Organic Chemistry including Medicinal Chemistry, 26 (11). pp. 1021-1024.
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Distamycin analog I was prepared in order to examine its DNA binding properties. Thus, condensation of $3-O_2NC_6H_4COCl$ with $3-H_2NC_6H_4CO_2Me$ (II), sapon., acid chlorination, and recondensation with II gave $3-O_2NC_6H_4CONHC_6H_4CO_2Me$ (III). Sapon. of III, acid chlorination, condensation with $H_2NCH_2CH_2CN$, hydrolysis, hydrogenation, and formylation gave I.
| Item Type: | Journal Article |
|---|---|
| Publication: | Indian Journal of Chemistry, Sect. B: Organic Chemistry including Medicinal Chemistry |
| Publisher: | Council of Scientific & Industrial Research |
| Additional Information: | Copyright of this article belongs to Council of Scientific & Industrial Research |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 18 Apr 2008 |
| Last Modified: | 27 Aug 2008 13:20 |
| URI: | http://eprints.iisc.ac.in/id/eprint/13763 |
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