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Handedness of duplex DNA: role of the glycosydic torsion

Rao, Shashidhar N and Sasisekharan, V (1983) Handedness of duplex DNA: role of the glycosydic torsion. In: International Journal of Biological Macromolecules, 5 (2). pp. 83-88.

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Model building studies on helical structures of polynucleotides indicate the glycosydic torsion, x, and the sugar pucker to be the most important conformational parameters in determining the handedness of the models. Sugar puckers in two typical regions of the pseudorotational space namely, $C2^{\prime}$ endo and $C3^{\prime}$ endo and the glycosydic torsion in four ranges, namely, anti, high anti, syn and low anti lead to eight conformational combinations for the model bulding of base-paired double helical structures of polynucleotides. Interestingly, not all combinations of sugar pucker and glycosidic torsion lead to structures with Watson-Crick base-pairing. The stereochemical details of the double stranded Watson-Crick base-paired models and their consistency with X-ray diffraction data are discussed.

Item Type: Journal Article
Publication: International Journal of Biological Macromolecules
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science
Keywords: DNA;duplex DNA;handedness;glycosydic torsion
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 10 Apr 2008
Last Modified: 19 Sep 2010 04:44
URI: http://eprints.iisc.ac.in/id/eprint/13663

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