Effect of Cobalt Chloride and 3-Amino-1,2,4-Triazole on the Induction of Cytochrome P-450 Synthesis by Phenobarbitone in Rat Liver

Ravishankar, Honnavar and Padmanaban, Govindarajan (1983) Effect of Cobalt Chloride and 3-Amino-1,2,4-Triazole on the Induction of Cytochrome P-450 Synthesis by Phenobarbitone in Rat Liver. In: Archives of Biochemistry and Biophysics, 225 (1). pp. 16-24.

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Abstract

Administration of cobalt chloride and 3-amino-1,2,4-triazole leads to a suppression of phenobarbitone-mediated increase in total cytochrome P-450 as well as cytochrome P-450b contents of the liver. This suppression is due to a decrease in the content of the protein species which is the result of a decrease in its rate of synthesis as measured in vivo and in vitro. Cobalt chloride as well as 3-amino-1,2,4-triazole treatments lead to a decrease in the translatability of cytochrome P-450b RNA without affecting total protein synthesis. It is a possibility that a small pool of heme regulates the RNA levels for the cytochrome P-450 species.

Item Type:	Journal Article
Publication:	Archives of Biochemistry and Biophysics
Publisher:	Elsevier Ltd
Additional Information:	Copyright of this article belongs to Elsevier Ltd.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Apr 2008
Last Modified:	19 Sep 2010 04:44
URI:	http://eprints.iisc.ac.in/id/eprint/13645

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