Investigations on the Mechanism of the Hypocholesterolemic Action of Diethylhexyl Phthalate in Rats

Nair, Nandini and Kurup, Ramakrishna CK (1986) Investigations on the Mechanism of the Hypocholesterolemic Action of Diethylhexyl Phthalate in Rats. In: Biochemical Pharmacology, 35 (20). pp. 3441-3447.

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Abstract

The plasticizer di(2-ethylhexyl)phthalate (DEHP), used widely in the manufacture of food packages and medical plastic devices, depressed serum cholesterol (40%) and proliferated hepatic mitochondria (100%) when administered in the diet (2%, w/w) to the rat. Microsomes isolated from the livers of animals administered DEHP showed lowered specific activity of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (50%). The incorporation of acetate but not of mevalonate into hepatic cholesterol was decreased (52%) in these animals. The release of bile acids was greatly enhanced (100%), and the activity of cholesterol 7\alpha-hydroxylase, the regulatory enzyme in the pathway of bile acid formation, was stimulated (70%) on DEHP administration. Even though the capacity of mitochondria to oxidize the side chain of cholesterol was not enhanced in DEHP-fed animals, the larger population of mitochondria would ensure that the amount of cholesterol oxidized pergram of liver was significantly higher.

Item Type:	Journal Article
Publication:	Biochemical Pharmacology
Publisher:	Elsevier Science Inc.
Additional Information:	Copyright of this article belongs to Elsevier Science Inc.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Apr 2008
Last Modified:	19 Sep 2010 04:44
URI:	http://eprints.iisc.ac.in/id/eprint/13582

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