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Alignment and phylogenetic analysis of type II DNA topoisomerases

Madhusudan, K and Nagaraja, V (1996) Alignment and phylogenetic analysis of type II DNA topoisomerases. In: Journal of Biosciences, 21 (5). pp. 613-629.


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DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation. This analysis shows the distinct evolutionary relatedness of type II DNA topoisomerases. A striking feature is the absence of a contiguous stretch of about 160 amino acids in one of the subunits of prokaryotic type II enzymes, which might have important implications to their structure and function.

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright for this article belongs to Indian Academy of Sciences.
Keywords: Type II DNA topoisomerases;DNA gyrase;multiple alignment;phylogenetic trees
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 03 Jan 2005
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ac.in/id/eprint/1351

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