Modified bases in transfer RNA

Brahmachari, Vani and Ramakrishnan, T (1984) Modified bases in transfer RNA. In: Journal of Biosciences, 6 (5). pp. 757-770.

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Abstract

Transfer RNA is uniquely enriched with modified bases. A large body of information has accumulated about the occurrence, nature and distribution of modified bases in tRNA. But similar investigations on the enzymes involved in this post-transcriptional modification have been hampered by the instability of the enzymes and lack of suitable substrates. The present review summarises briefly, the occurrence and methods of detection of modified bases, the enzymes involved in their formation and also certain suggestive evidence for the role of modification in cellular metabolism.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	tRNA;methyltransferases;methylation base modification;function
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	24 Mar 2008
Last Modified:	19 Sep 2010 04:43
URI:	http://eprints.iisc.ac.in/id/eprint/13440

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