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Oxidations in Kidney Mitochondria of Heat-Exposed Rats: Regulation by Cytochrome c

Puranam, RS and Shivaswamy, Vidya and Kurup, Ramakrishna CK and Ramasarma, T (1984) Oxidations in Kidney Mitochondria of Heat-Exposed Rats: Regulation by Cytochrome c. In: Journal of Bioenergetics and Biomembranes, 16 (6). pp. 421-431.

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Exposure of rats to higher environmental temperature (36-37°C) decreased the capacity of their kidney mitochondria to oxidize succinate. The decrease was corrected on the addition of exogenous cytochromec. Kidney mitochondria of heat-exposed animals showed decreased rates of $H_2O_2$ generation when \alpha-glycerophosphate, but not succinate, was used as electron donor. These mitochondria also showed decreased activity of \alpha-glycerophosphate dehydrogenase but not of succinate dehydrogenase. The content of cytochrome c in kidney mitochondria of heat-exposed animals was low even though the concentration of the pigment in the whole tissue did not decrease. Starvation as well as administration of an antithyroid agent like propylthiouracil simulated some of the effects of heat exposure on kidney mitochondria, but the cytochrome c-dependent reversal of inhibition of oxidation was obtained only in heat exposure.

Item Type: Journal Article
Publication: Journal of Bioenergetics and Biomembranes
Publisher: Springer Netherlands
Additional Information: Copyright of this article belongs to Springer Netherlands.
Keywords: Regulation of state 3 oxidation by cytochromec;decrease in H2O2 generation;aplha-glycerophosphate dehydrogenase;cytochromec in mitochondria;stress heat;propylthiouracil treatment;starvation
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 19 Mar 2008
Last Modified: 19 Sep 2010 04:43
URI: http://eprints.iisc.ac.in/id/eprint/13401

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