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Effect of vitamin A deprivation on the mitogenic factor activity in the rat testes

Unni, Emmanual and Kssari, KV and Rao, MRS (1984) Effect of vitamin A deprivation on the mitogenic factor activity in the rat testes. In: Biochemical and Biophysical Research Communications, 125 (2). pp. 454-462.

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The seminiferous tubules of rat testes contain a protease and heat sensitive factor capable of stimulating $(^3H)$-thymidine incorporation into quiescent cultures of NIH 3T3 mouse fibroblast cells. This mitogenic factor activity was only 4% in the testes of vitamin A deficient-retinoic acid maintained rats as compared to that of normal rats. Supplementation of retinyl acetate to these vitamin A deficient rats for 4 days resulted in a 56% recovery in the mitogenic factor activity while by day 16, the recovery was 80 percent. Incorporation of $(^3H)$-thymidine into DNA of the seminiferous tubules of vitamin A deficient rats was only 46% of that of normal rats which was restored to normal levels by retinyl acetate supplementation for 24 days.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier Inc
Additional Information: Copyright of this article belongs to Elsevier Inc.
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 19 Mar 2008
Last Modified: 19 Sep 2010 04:43
URI: http://eprints.iisc.ac.in/id/eprint/13400

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