Podder, SK and Chakraborti, A and Vijayalakshmi, K and Singh, P and Kumar, Lalit (1987) Reactivity of glycoconjugate in membrane system II: can a neutral glycolipid function as lectin receptor in the presence of gangliosides in plasma membrane. In: Journal of Biosciences, 11 (1-4). pp. 495-502.
Full text not available from this repository. (Request a copy)Abstract
To examine how surface potential controls the reactivity of glycoconjugates at the cell surface, the interaction of galactose-specific lectins, e.g. peanut agglutinin, Ricinus cummunis agglutinin, with liposomes bearing asialo ganglioside GM1 were studied in the presence of a varying amt. of ganglioside mixt., GMn. The presence of 5% GMn causes complete slowing down of the precipitin reaction and thereby make the carbohydrate moiety of asialo GM1 completely inaccessible, i.e. cryptic. In contrast, the presence of 1-2% GMn enhances the apparent rate and amplitude of the precipitin reaction as the surface potential becomes more neg. The relevance of the findings is discussed in relation to the expression and involvement of the cell-surface sialic acid residues during development and differentiation.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Biosciences |
| Publisher: | The Indian Academy of Sciences |
| Additional Information: | Copyright belongs to The Indian Academy of Sciences |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 18 Mar 2008 |
| Last Modified: | 27 Aug 2008 13:14 |
| URI: | http://eprints.iisc.ac.in/id/eprint/13234 |
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