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Pregnancy suppression in the bonnet monkey by active immunisation with chicken riboflavin carrier protein

Seshagiri, Polani B and Adiga, Radhakantha P (1987) Pregnancy suppression in the bonnet monkey by active immunisation with chicken riboflavin carrier protein. In: Journal of Reproductive Immunology, 12 (2). pp. 93-107.

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Official URL: http://dx.doi.org/10.1016/0165-0378(87)90038-6


Five healthy female bonnet monkeys (Macaca radiata) of proven fertility and normal menstrual cyclicity have been actively immunised with the purified chicken egg white riboflavin carrier protein (cRCP). All the immunised animals exhibited specific antibodies to cRCP and the immunopotencies of their sera varied at 200-840 \mu g/ml at equivalent point. A definite fraction of antibodies in these sera specifically recognized the purified and $^{125}I-labelled$ monkey RCP. Immunisation per se had no adverse effect on the animals menstrual cyclicity, circulating levels of estrogen and progesterone and the riboflavin status as reflected by glutathione reductase activities and the total flavin contents of the erythrocytes. The fertility of these animals was monitored for a period extending upto 3 years after primary immunisation. Four out of the 5 animals exhibited termination of pregnancy once or more than once depending on their antibody titers. Towards the end of the study period, when the immune response was poor, all the animals delivered normal babies at term. Circulating anti-cRCP antibodies were monitored by $^{125}I-labelled$ cRCP binding. The results show that pregnancy termination, owing to immuno-neutralization of monkey RCP, occurred only in animals which had sufficiently high antibody titers. If the titers fell below a critical threshold level the pregnancies were carried to term.

Item Type: Journal Article
Publication: Journal of Reproductive Immunology
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: bonnet monkey;active immunisation;riboflavin carrier protein (chicken, monkey);immuno-neutralisation;pregnancy suppression
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 17 Mar 2008
Last Modified: 01 Mar 2012 07:20
URI: http://eprints.iisc.ac.in/id/eprint/13218

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