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Structure of Puromycin Aminonucleoside

Padmaja, N and Ramakumar, S and Viswamitra, MA (1988) Structure of Puromycin Aminonucleoside. In: Acta Crystallographica, Section C: Crystal Structure Communications, C44 (12). pp. 2176-2178.

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3'-Amino-3'-deoxy-N,N-dimethyladenosine, $C_{12}H_{18}N_6O_3$, $M_r = 294.3$, monoclinic, $P2_1$, a = 4.684(1), b= 10.252(1), c= 14.381 (3)\AA, \beta = 91.16 (2)°, V= 690.49 $\AA^3$, Z = 2, $D_x = 1.39$ Mg $m^{-3}$, \lambda(Cu K\alpha) = 1.5418 \AA, \mu = 0.84 $mm^{-1}$, F(000) = 312, T= 295 K, R =0.045 for 986 observed reflections with I > 1.5\sigma(I). The adenine base is unprotonated at N(I) and is dimethylated at N(6). The nucleoside has a 3'-deoxy-3'-aminofuranosyl ribose sugar. The base is in the anti conformation (x= 2.3°) with respect to the furanosyl ring, which shows a C(3')-endo-C(2')-exo pucker $(_2T^3)$. 0(5') is disordered. The structure of the compound is similar to that of the nucleoside portion of the antibiotic puromycin.

Item Type: Journal Article
Publication: Acta Crystallographica, Section C: Crystal Structure Communications
Publisher: International Union of Crystallography
Additional Information: Copyright of this article belongs to International Union of Crystallography.
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 06 Mar 2008
Last Modified: 19 Sep 2010 04:42
URI: http://eprints.iisc.ac.in/id/eprint/13142

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